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The mean basal dimension of the tumor was 16 mm. Recombinant interferon alpha 2b for ocular surface squamous neoplasia: An efficient and cost-effective treatment modality in Asian Indian patients. Extensive surgical excision can result in limbal stem cell loss and ocular surface morbidity.
Topical agents offer the advantage of delivering treatment not only to the affected ocular surface but also to the entire ocular surface, and thus potentially eliminating subclinical OSSN, and also diminish the risk of limbal stem cell deficiency and associated ocular surface morbidity.
Methods This study is a retrospective study conducted at a single institution. The Institutional Review Board approval was obtained for the here. The study period ranged from August to December The demographic details age, gender were reviewed. Systemic history and past history were recorded. The recorded intext 100 free india dating features included tumor laterality, presenting complaints, duration of symptoms monthstumor location and extent conjunctiva, cornea, conjunctival-limbal-corneal surfacemaximum basal tumor diameter mmnumber of limbal clock hours involved by the tumor, and tumor pattern leukoplakic, gelatinous, nodular, papillary, placoid, pigmented.
The primary tumor was classified based on the American Joint Committee Classification, 7th edition. Locoregional lymph node examination and medical examination to rule out locoregional or systemic metastasis of tumor were performed in all cases.
The medication was packed in a thermocol icebox and two bottles of 5 ml each were dispatched to the patient at each visit during the treatment period. Every patient was reviewed once a month during the treatment period.
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Tumor details were recorded during each visit. If the patient had a residual tumor, the patient was advised to continue topical medication until complete tumor regression and 3 months beyond complete tumor regression.
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The additional perilesional injection was repeated every month in suitable cases. After complete tumor regression had been achieved, topical drops were continued for another 3 months.
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The histopathology details of excised tumor were recorded. After complete tumor regression had been achieved, the patients were reviewed once in 3 months in the first year and every 4 months in the second year.
The outcome was also analyzed based on maximum tumor dimension on presentation. The side effects of treatment and any event of tumor recurrence were noted. Of the thirty patients included in this study, the mean age at presentation was 55 years median: 57 years; range: 27—80 years. The intext 100 free india dating duration of symptoms was 12 months median: 7 months; range: 1—48 months.
The mean basal dimension of the tumor was 16 mm median: 20 mm; range: 4—30 mm. The mean number of limbal clock hours involved by the tumor was 6 median: 5; range: 1— Carcinoma in situ at one or more surgical margins was noted on histopathology.
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The residual tumor was surgically excised. On histopathology, both patients showed mild dysplasia. Table 3: Clinical features and treatment details of patients with ocular surface squamous neoplasia based on the response to treatment with interferon alpha 2b Click here to view Figure 1: Interferon alpha 2b as immunotherapy for extensive ocular surface squamous neoplasia.
Tumor regression was confirmed by map biopsy from 17 sites of the ocular surface.
No tumor recurrence was noted in any patient at a mean follow-up period of 9 months median: 7 months; range: 3—28 months. Two patients had to undergo surgical excision of the residual tumor, thus resulting in additional costs. Conflicts of interest There are no conflicts of interest.